CARBOHYDRATE-METABOLISM IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS

被引：222

作者：

DINNEEN, S

GERICH, J

RIZZA, R

机构：

[1] MAYO CLIN & MAYO FDN, DEPT MED,ENDOCRINE RES UNIT,RM 5-164, W JOSEPH BLDG, ROCHESTER, MN 55905 USA

[2] WHITTIER INST DIABET & ENDOCRINOL, DEPT BIOCHEM, LA JOLLA, CA USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1992年 / 327卷 / 10期

关键词：

D O I：

10.1056/NEJM199209033271007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

DIABETES mellitus is characterized by both fasting hyperglycemia and exaggerated postprandial increases in the plasma glucose level. Understanding the causes of these abnormalities is important for the rational use of current treatments and for developing more effective therapy. In this seminar, we review the physiology of normal carbohydrate metabolism and the pathophysiology of abnormalities in diabetes mellitus. Normal Physiology: Postabsorptive State The term “postabsorptive state” refers to the period 6 to 12 hours after a meal during which the transition from the postprandial to the fasting state occurs. At this time plasma glucose levels are at a nearly steady state;… © 1992, Massachusetts Medical Society. All rights reserved.

引用

页码：707 / 713

页数：7

共 65 条

[1] QUANTITATIVELY MINOR ROLE OF CARBOHYDRATE IN OXIDATIVE METABOLISM BY SKELETAL MUSCLE IN INTACT MAN IN THE BASAL STATE - MEASUREMENTS OF OXYGEN AND GLUCOSE UPTAKE AND CARBON DIOXIDE AND LACTATE PRODUCTION IN THE FOREARM [J].