The post-Paleozoic metallogenic evolution of southeastern Peru is clarified on the basis of the stratigraphic and lithologic settings of the majority of the known metallic ore deposits and a regional program of K-Ar and 40Ar 39Ar geochronology. This central Andean transect displays a range of mineralization types unparalleled in other regions of the country. Contrasting magmatic, tectonic, and metallogenic relationships are shown by the calc-alkaline-shoshonitic Upper Triassic-Holocene Main Arc magmatic domain, underlying the present Cordillera Occidental and Altiplano, and the more restricted Triassic-Pliocene Inner Arc domain of the Cordillera Oriental, which incorporates a great variety of igneous suites and exhibits a correspondingly diverse metallogeny. Major economic mineralization occurred simultaneously in the two domains only during the late Oligocene to early Miocene interval. The post-Paleozoic metallogenic evolution of southeastern Peru is clarified on the basis of the stratigraphic and lithologic settings of the majority of the known metallic ore deposits and a regional program of K-Ar and 40Ar 39Ar geochronology. This central Andean transect displays a range of mineralization types unparalleled in other regions of the country. Contrasting magmatic, tectonic, and metallogenic relationships are shown by the calc-alkaline-shoshonitic Upper Triassic-Holocene Main Arc magmatic domain, underlying the present Cordillera Occidental and Altiplano, and the more restricted Triassic-Pliocene Inner Arc domain of the Cordillera Oriental, which incorporates a great variety of igneous suites and exhibits a correspondingly diverse metallogeny. Major economic mineralization occurred simultaneously in the two domains only during the late Oligocene to early Miocene interval. The post-Paleozoic metallogenic evolution of southeastern Peru is clarified on the basis of the stratigraphic and lithologic settings of the majority of the known metallic ore deposits and a regional program of K-Ar and 40Ar 39Ar geochronology. This central Andean transect displays a range of mineralization types unparalleled in other regions of the country. Contrasting magmatic, tectonic, and metallogenic relationships are shown by the calc-alkaline-shoshonitic Upper Triassic-Holocene Main Arc magmatic domain, underlying the present Cordillera Occidental and Altiplano, and the more restricted Triassic-Pliocene Inner Arc domain of the Cordillera Oriental, which incorporates a great variety of igneous suites and exhibits a correspondingly diverse metallogeny. Major economic mineralization occurred simultaneously in the two domains only during the late Oligocene to early Miocene interval. The post-Paleozoic metallogenic evolution of southeastern Peru is clarified on the basis of the stratigraphic and lithologic settings of the majority of the known metallic ore deposits and a regional program of K-Ar and 40Ar 39Ar geochronology. This central Andean transect displays a range of mineralization types unparalleled in other regions of the country. Contrasting magmatic, tectonic, and metallogenic relationships are shown by the calc-alkaline-shoshonitic Upper Triassic-Holocene Main Arc magmatic domain, underlying the present Cordillera Occidental and Altiplano, and the more restricted Triassic-Pliocene Inner Arc domain of the Cordillera Oriental, which incorporates a great variety of igneous suites and exhibits a correspondingly diverse metallogeny. Major economic mineralization occurred simultaneously in the two domains only during the late Oligocene to early Miocene interval. The post-Paleozoic metallogenic evolution of southeastern Peru is clarified on the basis of the stratigraphic and lithologic settings of the majority of the known metallic ore deposits and a regional program of K-Ar and 40Ar 39Ar geochronology. This central Andean transect displays a range of mineralization types unparalleled in other regions of the country. Contrasting magmatic, tectonic, and metallogenic relationships are shown by the calc-alkaline-shoshonitic Upper Triassic-Holocene Main Arc magmatic domain, underlying the present Cordillera Occidental and Altiplano, and the more restricted Triassic-Pliocene Inner Arc domain of the Cordillera Oriental, which incorporates a great variety of igneous suites and exhibits a correspondingly diverse metallogeny. Major economic mineralization occurred simultaneously in the two domains only during the late Oligocene to early Miocene interval.