MOLECULAR ANALYSIS OF THE ASSOCIATION OF HLA-B53 AND RESISTANCE TO SEVERE MALARIA

被引：587

作者：

HILL, AVS

ELVIN, J

WILLIS, AC

AIDOO, M

ALLSOPP, CEM

GOTCH, FM

GAO, XM

TAKIGUCHI, M

GREENWOOD, BM

TOWNSEND, ARM

MCMICHAEL, AJ

WHITTLE, HC

机构：

[1] UNIV OXFORD,DEPT BIOCHEM,MRC,IMMUNOCHEM UNIT,OXFORD OX1 3QU,ENGLAND

[2] MRC LABS,BANJUL,SENEGAMBIA

[3] UNIV TOKYO,INST MED SCI,MINAMI KU,TOKYO 108,JAPAN

来源：

NATURE | 1992年 / 360卷 / 6403期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/360434a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide from liver-stage-specific antigen-1 (LSA-1), but no HLA-B53-restricted epitopes were identified in other antigens. These findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component.

引用

页码：434 / 439

页数：6

共 65 条

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