SYNTHESIS OF N-SUBSTITUTED 7-BETA-DIPRENORPHINE DERIVATIVES

被引：17

作者：

MARTON, J

MIKLOS, S

HOSZTAFI, S

MAKLEIT, S

机构：

[1] ALKALOIDA CHEM CO LTD,H-4440 TISZAVASVARI,HUNGARY

[2] LAJOS KOSSUTH UNIV,DEPT ORGAN CHEM,H-4010 DEBRECEN,HUNGARY

来源：

SYNTHETIC COMMUNICATIONS | 1995年 / 25卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1080/00397919508013419

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The separation of thevinone (2a) and beta-thevinone (2b), as well as that of dihydrothevinone (3a) and beta-dihydrothevinone (3b) was accomplished. By the application of various procedures numerous new N-substituted Diprenorphine analogues (8a-f) with 7R absolute configuration were synthesized. Detailed pharmacological investigation of the prepared compounds may contribute to a better understanding of the structure-activity relationship of morphine alkaloids.

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页码：829 / 848

页数：20

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