RESTRICTIONS TO FLOOR PLATE INDUCTION BY HEDGEHOG AND WINGED-HELIX GENES IN THE NEURAL-TUBE OF FROG EMBRYOS

被引：100

作者：

ALTABA, ARI

JESSEL, TM

ROELINK, H

机构：

[1] Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University Medical Center, New York, NY 10016

[2] Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University, New York, NY 10032

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 1995年 / 6卷 / 02期

关键词：

D O I：

10.1006/mcne.1995.1011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intercellular signaling molecules of the vertebrate hedgehog family and transcription factors of the winged-helix family have been implicated in floor plate development. We have examined the consequences of misexpressing the vertebrate hedgehog gene vhh-1 (sonic hedgehog, shh) and the winged-helix gene HNF-3 beta in the neural plate and neural tube of frog embryos. Misexpression of either of these genes induces floor plate differentiation at ectopic locations. However, ectopic floor plate induction in response to both vhh-1 and HNF-3 beta was temporally and spatially restricted. At neural plate stages, ectopic floor plate differentiation was not detected. After neural tube closure, ectopic floor plate differentiation was detected but was restricted predominantly to the dorsal region of the neural tube. The ability of winged-helix and vertebrate hedgehog genes to induce floor plate differentiation in vivo may, therefore, be constrained by additional signals that specify the time and position of floor plate differentiation. (C) 1995 Academic Press, Inc.

引用

页码：106 / 121

页数：16

共 58 条

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