VERAPAMIL BLOCKS BASAL AND ANGIOTENSIN-II-INDUCED RNA-SYNTHESIS OF RAT AORTIC VASCULAR SMOOTH-MUSCLE CELLS

被引：17

作者：

ANDRAWIS, NS ^{[1
]}

ABERNETHY, DR ^{[1
]}

机构：

[1] ROGER WILLIAMS MED CTR,DIV CLIN PHARMACOL,PROVIDENCE,RI

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90549-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We evaluated VER effect on RNA synthesis of quiescent and angiotensin II (AII)- stimulated cultured rat aortic vascular smooth muscle cells (VSMC). In a dose-dependent manner, VER decreased [3H]uridine uptake by quiescent VSMCs (ED50 7×10-6M), an effect that was shared by other calcium antagonists, but to a variable degree. VER caused a significant effect within 3 hours and attained a maximal effect at 7 hours. In addition VER caused a 22±2% decrease in [3H]uridine uptake by VSMCs stimulated with 10% fetal bovine serum, while it completely abolished [3H]uridine uptake by VSMCs induced by AII. We conclude that VER decreases basal and inhibits AII-induced increase in mRNA synthesis of VSMCs. These data may explain in part how VER causes a decrease in vascular resistance and alters the vasoconstrictor effect of AII. © 1992.

引用

页码：767 / 773

页数：7

共 25 条

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