MUTAGENIC STEROL HYDROPEROXIDES

被引：20

作者：

SMITH, LL ^{[1
]}

SMART, VB ^{[1
]}

GOWDA, NMM ^{[1
]}

机构：

[1] UNIV TEXAS, MED BRANCH, DEPT HUMAN BIOL CHEM & GENET, DIV BIOCHEM, GALVESTON, TX 77550 USA

来源：

MUTATION RESEARCH | 1986年 / 161卷 / 01期

关键词：

D O I：

10.1016/0027-5107(86)90098-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sterol hydroperoxides 3.beta.-hydroxy-5.alpha.-cholest-6-ene-5-hydroperoxide and 3.beta.-hydroxycholest-5-ene-7.alpha.-hydroperoxide show weak dose-response direct mutagenicity towards Salmonella typhimurium strain TA1537 in a liquid medium incubation bioassay. Responses were comprised by metabolism of the sterol hydroxyperoxides and by phase separation during the incubation period. Mutagenicity responses were increased by added superoxide dismutase but diminished by added rat liver S9 enzymes and abolished by added catalase. Catalase also abolished the stimulatory effect of superoxide dismutase. These results indicate that superoxide and peroxide be implicated in the mutagenicity responses.

引用

页码：39 / 48

页数：10

共 45 条

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