DEPROTECTION AND CLEAVAGE METHODS FOR PROTECTED PEPTIDE RESINS CONTAINING 4-[(DIETHYLPHOSPHONO)DIFLUOROMETHYL]-D,L-PHENYLALANINE RESIDUES

被引：32

作者：

OTAKA, A

BURKE, TR

SMYTH, MS

NOMIZU, M

ROLLER, PP

机构：

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(00)61591-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl groups on 4-[(diethylphosphono)difluoromethyl]-D,L-phenylalanine are efficiently removed using S(N)2-type acidic reagents. These methods were utilized for the solid-phase synthesis of SH2-binding peptides containing nonhydrolyzable phosphotyrosyl mimetics.

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页码：7039 / 7042

页数：4

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