ACTIVATION OF A K-252B-SENSITIVE PROTEIN-KINASE IS NECESSARY FOR A POSTSYNAPTIC PHASE OF LONG-TERM POTENTIATION IN AREA CA1 OF RAT HIPPOCAMPUS

被引:57
作者
REYMANN, KG
DAVIES, SN
MATTHIES, H
KASE, H
COLLINGRIDGE, GL
机构
[1] UNIV BRISTOL,SCH MED SCI,DEPT PHARMACOL,UNIV WALK,BRISTOL BS8 1TD,AVON,ENGLAND
[2] ACAD SCI GDR,INST NEUROBIOL & BRAIN RES,O-3090 MAGDEBURG,GERMANY
[3] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,MACHIDA,TOKYO 194,JAPAN
基金
英国惠康基金;
关键词
AMPA; LTP; PKC; Plasticity;
D O I
10.1111/j.1460-9568.1990.tb00439.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
K‐252b, a potent inhibitor of protein kinases blocked a late phase of long‐term potentiation (LTP) in area CA1 of rat hippocampal slices, resulting in decremental LTP. It also prevented the slowly developing increase in sensitivity of CA1 neurons to iontophoretically administered α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) which was seen in control slices that exhibit nondecremental LTP. However, K‐252b applied 60–180 min after the induction of LTP had no effect on the potentiated synaptic and AMPA‐induced responses. A K‐252b‐sensitive protein kinase may therefore be involved in a slowly developing postsynaptic component of LTP. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:481 / 486
页数:6
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