INTERMOLECULAR AND INTRAMOLECULAR HETERO-DIELS-ALDER REACTIONS .29. SYNTHESIS OF ENANTIOMERICALLY PURE HETEROSTEROIDS BY INTRAMOLECULAR HETERO-DIELS-ALDER REACTION

被引：42

作者：

TIETZE, LF ^{[1
]}

BEIFUSS, U ^{[1
]}

LOKOS, M ^{[1
]}

RISCHER, M ^{[1
]}

GOHRT, A ^{[1
]}

SCHELDRICK, GM ^{[1
]}

机构：

[1] UNIV GOTTINGEN,INST ANORGAN CHEM,W-3400 GOTTINGEN,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 05期

关键词：

D O I：

10.1002/anie.199005271

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A tandem Knoevenagel/hetero‐Diels–Alder reaction of the aldehyde 2 with the cyclic 1,3‐dioxo compound 1 and its analogues leads stereoselectively to the trans‐bonded heterosteroids 3 (de > 98%). Aldehyde 2 is obtained by ozonolysis of enantiomerically pure tetrahydroindanone derivatives, which are in turn readily available by the Wiechert‐Hajos procedure. (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：527 / 529

页数：3

共 43 条

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