SERUM ALPHA-1-MICROGLOBULIN AND BETA-2-MICROGLOBULIN FOR THE ESTIMATION OF FETAL GLOMERULAR RENAL-FUNCTION

被引：44

作者：

NOLTE, S

MUELLER, B

PRINGSHEIM, W

机构：

[1] Universitäts-Kinderklinik, Freiburg, W-7800

来源：

PEDIATRIC NEPHROLOGY | 1991年 / 5卷 / 05期

关键词：

ALPHA-1-MICROGLOBULIN; BETA-2-MICROGLOBULIN; CREATININE; NEONATE; FETAL KIDNEY FUNCTION;

D O I：

10.1007/BF00856641

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

As proteins cannot cross the placenta levels of the microproteins alpha-1-microglobulin (alpha-1MG) and beta-2-microglobulin (beta-2MG) can be used to assess fetal glomerular renal function. Alpha-1MG, beta-2MG and creatinine were routinely determined in cord and maternal blood of 133 newborns [gestational age (GA) 25-42 weeks]. Twenty-nine patients with suspected impaired maternal or fetal renal function were studied separately and two fetuses were studied in utero. The mean fetal beta-2MG concentration fell from 3.87 +/- 0.56 mg/l in the 25-31 weeks GA group to 2.60 +/- 0.50 mg/l in the mature newborn group. Alpha-1MG concentration fell from 3.10 +/- 0.51 to 2.25 +/- 0.49 mg/dl. In contrast, the mean maternal beta-1MG concentration rose from 1.73 +/- 0.69 mg/l in the 25 - 31 weeks GA group to a mean of 1.83 +/- 0.48 mg/l in the mature newborn group; alpha-1MG rose from 3.96 +/- 0.58 to 4.33 +/- 1.6 mg/dl. Maternal and fetal creatinine levels were identical. Fetal microprotein levels fall during intra-uterine development as glomerular filtration rate (GFR) rises. There is no correlation between cord blood and maternal alpha-1MG or beta-2MG concentrations. In 13 children with urological anomalies only 1 had elevated microprotein levels and he later developed renal insufficiency. Determination of microprotein levels in fetal serum can be used to detect severe renal function disturbances and to estimate GFR independently of maternal renal function.

引用

页码：573 / 577

页数：5

共 24 条

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