CALCIUM-CALMODULIN-DEPENDENT ACTIVATION OF ADENYLATE-CYCLASE IN PROSTAGLANDIN-INDUCED ELECTRICALLY-MONITORED INTESTINAL SECRETION IN THE RAT

被引：13

作者：

HARDCASTLE, J ^{[1
]}

HARDCASTLE, PT ^{[1
]}

AYTON, B ^{[1
]}

CHAPMAN, J ^{[1
]}

MACNEIL, S ^{[1
]}

机构：

[1] NO GEN HOSP,CTR CLIN SCI,DEPT MED,SHEFFIELD S5 7AU,S YORKSHIRE,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 02期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb03568.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The calcium-calmodulin antagonist 5-iodo-C-8-W7 inhibited the PGE2-induced stimulation of cAMP production by isolated enterocytes from rat small intestine. It also reduced the secretory response of intestinal sheets to PGE2, measured as a rise in short-circuit current. It did not however, inhibit the electrical responses to forskolin and dibutyryl cAMP, nor to acetylcholine, a secretagogue whose effect is not mediated by cAMP. It is concluded that the receptor-mediated activation of adenylate cyclase and the subsequent secretory response are dependent upon calcium-calmodulin.

引用

页码：93 / 96

页数：4

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