NEISSERIA-GONORRHOEAE IGA1 PROTEASES SHARE EPITOPES RECOGNIZED BY NEUTRALIZING ANTIBODIES

被引:8
作者
LOMHOLT, H
LIND, I
KILIAN, M
机构
[1] AARHUS UNIV,INST MED MICROBIOL,DK-8000 AARHUS C,DENMARK
[2] STATENS SERUM INST,WHO,COLLABORATING CTR REFERENCE & RES GONOCOCCI,COPENHAGEN,DENMARK
关键词
NEISSERIA GONORRHOEAE; GONORRHEA; VACCINE; IGA1; PROTEASE; MUCOSAL IMMUNITY;
D O I
10.1016/0264-410X(95)00057-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The antigenic diversity among IgA1 proteases of 61 Neisseria gonorrhoeae strains isolated during a period of 23 years and on four continents was examined in enzyme neutralization assays employing rabbit antisera raised against selected IgA1 proteases. The antigenic analyses were compared with results of iga gene-region RFLP patterns and enzyme cleavage specificity for substrate IgA1, Type I IgA1 proteases weve antigenically uniform while six different antigenic types were detected among type 2 enzymes, Extensive cross-reactions of antibodies against the different antigenic types suggested only minor differences in relevant epitopes, Epitopes previously found to be common to all Neisseria meningitidis IgA1 proteases were also shaved by all N. gonorrhoeae IgA1 proteases in the collection, Human sera from patients with gonorrhoea showed broadly cross-reactive neutralizing activity at titers comparable to those of sera from immunized rabbits. In conclusion, N, gonorrhoeae IgA1 proteases show a remarkable lack of diversity of epitopes recognized by enzyme-neutralizing antibodies. If future studies confirm that cleavage of IgA1 is an important step in gonococcal infections, Neisseria IgA1 proteases may be attractive vaccine candidates.
引用
收藏
页码:1213 / 1219
页数:7
相关论文
共 48 条
[1]   STUDIES ON GONOCOCCUS INFECTION .17. IGA1-CLEAVING PROTEASE IN VAGINAL WASHINGS FROM WOMEN WITH GONORRHEA [J].
BLAKE, M ;
HOLMES, KK ;
SWANSON, J .
JOURNAL OF INFECTIOUS DISEASES, 1979, 139 (01) :89-92
[2]   EFFICACY TRIAL OF A PARENTERAL GONOCOCCAL PILUS VACCINE IN MEN [J].
BOSLEGO, JW ;
TRAMONT, EC ;
CHUNG, RC ;
MCCHESNEY, DG ;
CIAK, J ;
SADOFF, JC ;
PIZIAK, MV ;
BROWN, JD ;
BRINTON, CC ;
WOOD, SW ;
BRYAN, JR .
VACCINE, 1991, 9 (03) :154-162
[3]   ANTIBODIES AGAINST IGA1 PROTEASE ARE STIMULATED BOTH BY CLINICAL-DISEASE AND ASYMPTOMATIC CARRIAGE OF SEROGROUP-A NEISSERIA-MENINGITIDIS [J].
BROOKS, GF ;
LAMMEL, CJ ;
BLAKE, MS ;
KUSECEK, B ;
ACHTMAN, M .
JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (06) :1316-1321
[4]  
FISHMAN Y, 1985, PATHOGENIC NEISSERIA, P164
[5]   INHIBITION OF MICROBIAL IGA PROTEASES BY HUMAN SECRETORY IGA AND SERUM [J].
GILBERT, JV ;
PLAUT, AG ;
LONGMAID, B ;
LAMM, ME .
MOLECULAR IMMUNOLOGY, 1983, 20 (09) :1039-1049
[6]   MOSAIC-LIKE ORGANIZATION OF IGA PROTEASE GENES IN NEISSERIA-GONORRHOEAE GENERATED BY HORIZONTAL GENETIC EXCHANGE INVIVO [J].
HALTER, R ;
POHLNER, J ;
MEYER, TF .
EMBO JOURNAL, 1989, 8 (09) :2737-2744
[7]   IGA PROTEASE OF NEISSERIA-GONORRHOEAE - ISOLATION AND CHARACTERIZATION OF THE GENE AND ITS EXTRACELLULAR PRODUCT [J].
HALTER, R ;
POHLNER, J ;
MEYER, TF .
EMBO JOURNAL, 1984, 3 (07) :1595-1601
[8]   INDUCTION OF SPECIFIC IMMUNOGLOBULIN-A IN THE SMALL-INTESTINE, COLON-RECTUM, AND VAGINA MEASURED BY A NEW METHOD FOR COLLECTION OF SECRETIONS FROM LOCAL MUCOSAL SURFACES [J].
HANEBERG, B ;
KENDALL, D ;
AMERONGEN, HM ;
APTER, FM ;
KRAEHENBUHL, JP ;
NEUTRA, MR .
INFECTION AND IMMUNITY, 1994, 62 (01) :15-23
[9]  
HARBOE NMG, 1983, SCAND J IMMUNOL S10, V17, P345
[10]   NEW METHOD FOR OBTAINING IGA-SPECIFIC PROTEASE [J].
HIGERD, TB ;
VIRELLA, G ;
CARDENAS, R ;
KOISTINEN, J ;
FETT, JW .
JOURNAL OF IMMUNOLOGICAL METHODS, 1977, 18 (3-4) :245-249