ON A CAUSAL MECHANISM OF CHRONIC THYMIC INVOLUTION IN MAN

被引：49

作者：

HARTWIG, M ^{[1
]}

STEINMANN, G ^{[1
]}

机构：

[1] BOEHRINGER INGELHEIM DEUTSCHLAND GMBH, D-88397 BIBERACH, GERMANY

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1994年 / 75卷 / 02期

关键词：

MAMMALIAN AGING; THYMUS INVOLUTION;

D O I：

10.1016/0047-6374(94)90083-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The age-associated chronic thymus involution is interpreted to occur due to cytolytic depletion of thymic stromal tissue whose cells present altered self-peptides. Using simplified assumptions and based on morphometric data on thymic involution in man, the chance for a single protein to be altered is estimated to be in the range of 2-4 x 10-(6) per year. The corresponding mutation rate is compatible with that derived from both evolutionary and direct studies, thus supporting the proposed model.

引用

页码：151 / 156

页数：6

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