DEVELOPMENTALLY REGULATED MESSENGER-RNAS IN MOUSE-LIVER

被引：75

作者：

BARTH, RK ^{[1
]}

GROSS, KW ^{[1
]}

GREMKE, LC ^{[1
]}

HASTIE, ND ^{[1
]}

机构：

[1] NEW YORK STATE DEPT HLTH, ROSWELL PK MEM INST, DEPT MOLEC BIOL, BUFFALO, NY 14263 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1982年 / 79卷 / 02期

关键词：

D O I：

10.1073/pnas.79.2.500

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mouse liver contains a group of 10-12 different tissue-specific mRNA, each present at an average concentration of 12,000-15,000 copies/cell. These mRNA are developmentally regulated in the liver. The developmental time course of expression of 5 different abundant liver mRNA. There are at least 3 periods during liver development when specific abundant mRNA are first detectable; prior to 14 days postconception, at birth and during the onset of sexual maturity. All the members of this mRNA group are apparently not under common developmental regulation. One of the abundant liver mRNA (p54 mRNA) increases > 1000-fold in the liver 1 day before birth. Factors that may be involved in the developmental regulation of expression of the genes encoding these mRNA are discussed.

引用

页码：500 / 504

页数：5

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