MM-55266 AND MM-55268, GLYCOPEPTIDE ANTIBIOTICS PRODUCED BY A NEW STRAIN OF AMYCOLATOPSIS - ISOLATION, PURIFICATION AND STRUCTURE DETERMINATION

被引：7

作者：

BOX, SJ ^{[1
]}

COATES, NJ ^{[1
]}

DAVIS, CJ ^{[1
]}

GILPIN, ML ^{[1
]}

HOUGEFRYDRYCH, CSV ^{[1
]}

MILNER, PH ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,CHEMOTHERAPEUT RES CTR,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 08期

关键词：

D O I：

10.7164/antibiotics.44.807

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two novel glycopeptide antibiotics MM 55266 and MM 55268 containing fatty acid acyl functions, and of molecular formula C86H89N8O35Cl5 and C87H91N8O35Cl5, respectively, have been isolated and identified from a complex produced by Amycolatopsis sp. NCIB 40089. Fermentation conditions for their production, and methods for their isolation are described. Structures have been deduced by use of COSY and NOE NMR techniques and supported by chemical degradation studies. Both glycopeptides possessed good antibacterial activity against Gram-positive organisms.

引用

页码：807 / 813

页数：7

共 9 条

[1] STRUCTURE ELUCIDATION OF A GLYCOPEPTIDE ANTIBIOTIC, OA-7653 [J].

ANG, SG ;

WILLIAMSON, MP ;

WILLIAMS, DH .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (07) :1949-1956

[2] PARVODICIN, A NOVEL GLYCOPEPTIDE FROM A NEW SPECIES, ACTINOMADURA-PARVOSATA - DISCOVERY, TAXONOMY, ACTIVITY AND STRUCTURE ELUCIDATION [J].

CHRISTENSEN, SB ;

ALLAUDEEN, HS ;

BURKE, MR ;

CARR, SA ;

CHUNG, SK ;

DEPHILLIPS, P ;

DINGERDISSEN, JJ ;

DIPAOLO, M ;

GIOVENELLA, AJ ;

HEALD, SL ;

KILLMER, LB ;

MICO, BA ;

MUELLER, L ;

PAN, CH ;

POEHLAND, BL ;

RAKE, JB ;

ROBERTS, GD ;

SHEARER, MC ;

SITRIN, RD ;

NISBET, LJ ;

JEFFS, PW .

JOURNAL OF ANTIBIOTICS, 1987, 40 (07) :970-990

[3] BIOSYNTHETIC-STUDIES OF ARIDICIN ANTIBIOTICS .1. LABELING PATTERNS AND OVERALL PATHWAYS [J].

CHUNG, SK ;

TAYLOR, P ;

OH, YK ;

DEBROSSE, C ;

JEFFS, PW .

JOURNAL OF ANTIBIOTICS, 1986, 39 (05) :642-651

[4] ISOLATION AND CHARACTERIZATION OF A41030, A COMPLEX OF NOVEL GLYCOPEPTIDE ANTIBIOTICS - APPLICATION OF THE MICHEL-MILLER HIGH-PERFORMANCE LOW-PRESSURE LIQUID-CHROMATOGRAPHY SYSTEM [J].

EGGERT, JH ;

MICHEL, KH .

JOURNAL OF ANTIBIOTICS, 1986, 39 (06) :792-799

[5] KIBDELINS (AAD-609), NOVEL GLYCOPEPTIDE ANTIBIOTICS .2. ISOLATION, PURIFICATION AND STRUCTURE [J].

FOLENAWASSERMAN, G ;

POEHLAND, BL ;

YEUNG, EWK ;

STAIGER, D ;

KILLMER, LB ;

SNADER, K ;

DINGERDISSEN, JJ ;

JEFFS, PW .

JOURNAL OF ANTIBIOTICS, 1986, 39 (10) :1395-1406

[6] TEICOPLANIN, ANTIBIOTICS FROM ACTINOPLANES-TEICHOMYCETICUS NOV-SP .7. PREPARATION AND NMR CHARACTERISTICS OF THE AGLYCONE OF TEICOPLANIN [J].

MALABARBA, A ;

FERRARI, P ;

GALLO, GG ;

KETTENRING, J ;

CAVALLERI, B .

JOURNAL OF ANTIBIOTICS, 1986, 39 (10) :1430-1442

[7] TEICOPLANIN, ANTIBIOTICS FROM ACTINOPLANES-TEICHOMYCETICUS NOV-SP .6. CHEMICAL DEGRADATION - PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF ACID-HYDROLYSIS PRODUCTS [J].

MALABARBA, A ;

STRAZZOLINI, P ;

DEPAOLI, A ;

LANDI, M ;

BERTI, M ;

CAVALLERI, B .

JOURNAL OF ANTIBIOTICS, 1984, 37 (09) :988-999

[8] ASPECTS OF MOLECULAR RECOGNITION - SOLVENT EXCLUSION AND DIMERIZATION OF THE ANTIBIOTIC RISTOCETIN WHEN BOUND TO A MODEL BACTERIAL CELL-WALL PRECURSOR [J].

WALTHO, JP ;

WILLIAMS, DH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (07) :2475-2480

[9] STRUCTURE ELUCIDATION OF THE GLYCOPEPTIDE ANTIBIOTIC COMPLEX A40926 [J].

WALTHO, JP ;

WILLIAMS, DH .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1987, (09) :2103-2107

← 1 →