学术探索
学术期刊
新闻热点
数据分析
智能评审

TAMOXIFEN UP-REGULATES C-ERBB-2 EXPRESSION IN ESTROGEN-RESPONSIVE BREAST-CANCER CELLS-INVITRO

被引：62
作者：
ANTONIOTTI, S
MAGGIORA, P
DATI, C
DEBORTOLI, M
机构：
[1] DIPARTIMENTO BIOL ANIM,VIA ACCADEMIA ALBERTINA 17,I-10123 TURIN,ITALY
[2] UNIV TURIN,DEPT ANIM BIOL,MOLEC CELL BIOL,I-10124 TURIN,ITALY
来源：
EUROPEAN JOURNAL OF CANCER | 1992年 / 28A卷 / 2-3期
关键词：
D O I：
10.1016/S0959-8049(05)80045-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Expression of the c-erbB-2 proto-oncogene is inhibited by oestrogens in oestrogen-responsive human breast cancer cells, at both mRNA and protein level. Here we report that, where the regulation of c-erbB-2 is concerned, tamoxifen displays a full anti-oestrogenic activity, enhancing the expression of c-erbB-2 in oestrogen receptor-positive cells cultured with untreated fetal calf serum or reversing the inhibitory effect of added oestrogens. Meanwhile, tamoxifen strongly inhibited cell growth. Tamoxifen was inactive on both c-erbB-2 expression and growth of oestrogen receptor-negative cells. These results may have important implications to explain occasional failure of tamoxifen therapy in oestrogen receptor-positive breast cancers.
引用
收藏
页码：318 / 321
页数：4
相关论文
共 24 条
[1]  
BORG A, 1990, CANCER RES, V50, P4332
[2]  
BORG A, 1991, ONCOGENE, V6, P137
[3]   STOCHASTIC APPEARANCE OF MAMMARY-TUMORS IN TRANSGENIC MICE CARRYING THE MMTV/C-NEU ONCOGENE [J].
BOUCHARD, L ;
LAMARRE, L ;
TREMBLAY, PJ ;
JOLICOEUR, P .
CELL, 1989, 57 (06) :931-936
[4]   C-ERBB-2 AND RAS EXPRESSION LEVELS IN BREAST-CANCER ARE CORRELATED AND SHOW A COOPERATIVE ASSOCIATION WITH UNFAVORABLE CLINICAL OUTCOME [J].
DATI, C ;
MURACA, R ;
TAZARTES, O ;
ANTONIOTTI, S ;
PERROTEAU, I ;
GIAI, M ;
CORTESE, P ;
SISMONDI, P ;
SAGLIO, G ;
DEBORTOLI, M .
INTERNATIONAL JOURNAL OF CANCER, 1991, 47 (06) :833-838
[5]  
DATI C, 1990, ONCOGENE, V5, P1001
[6]   ERBB-2 IS A POTENT ONCOGENE WHEN OVEREXPRESSED IN NIH/3T3 CELLS [J].
DIFIORE, PP ;
PIERCE, JH ;
KRAUS, MH ;
SEGATTO, O ;
KING, CR ;
AARONSON, SA .
SCIENCE, 1987, 237 (4811) :178-182
[7]   VARIOUS RAT ADULT TISSUES EXPRESS ONLY ONE MAJOR MESSENGER-RNA SPECIES FROM THE GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE MULTIGENIC FAMILY [J].
FORT, P ;
MARTY, L ;
PIECHACZYK, M ;
ELSABROUTY, S ;
DANI, C ;
JEANTEUR, P ;
BLANCHARD, JM .
NUCLEIC ACIDS RESEARCH, 1985, 13 (05) :1431-1442
[8]   EXPRESSION OF THE C-ERBB-2 PROTEIN IN NORMAL AND TRANSFORMED-CELLS [J].
GULLICK, WJ ;
BERGER, MS ;
BENNETT, PLP ;
ROTHBARD, JB ;
WATERFIELD, MD .
INTERNATIONAL JOURNAL OF CANCER, 1987, 40 (02) :246-254
[9]  
HUDSON LG, 1990, J BIOL CHEM, V265, P4389
[10]   P185HER2 MONOCLONAL-ANTIBODY HAS ANTIPROLIFERATIVE EFFECTS INVITRO AND SENSITIZES HUMAN-BREAST TUMOR-CELLS TO TUMOR NECROSIS FACTOR [J].
HUDZIAK, RM ;
LEWIS, GD ;
WINGET, M ;
FENDLY, BM ;
SHEPARD, HM ;
ULLRICH, A .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (03) :1165-1172
123