POTENTIATION OF THE IN-VITRO ACTIVITY OF SOME ANTIMICROBIAL AGENTS AGAINST SELECTED GRAM-NEGATIVE BACTERIA BY EDTA-TROMETHAMINE

被引：19

作者：

FARCA, AM ^{[1
]}

NEBBIA, P ^{[1
]}

RE, G ^{[1
]}

机构：

[1] UNIV TURIN,DEPT EPIDEMIOL ANIM PROD & ECOL,DIV INFECT DIS,I-10124 TURIN,ITALY

来源：

VETERINARY RESEARCH COMMUNICATIONS | 1993年 / 17卷 / 02期

关键词：

ANTIBIOTICS; BACTERIA; GRAM-NEGATIVE; EDTA; ETHYLENEDIAMINETETRAACETIC ACID; MINIMAL INHIBITORY CONCENTRATION; POTENTIATION; TROMETHAMINE;

D O I：

10.1007/BF01839235

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The in vitro synergistic effects of combinations of EDTA-tromethamine and six antimicrobial agents (ampicillin, chloramphenicol, oxytetracycline, streptomycin, nalidixic acid and sulphadimethoxine) on clinically isolatcd strains of Pseudomonas aeruginosa, Proteus mirabilis and Escherichia coli were investigated. The antibacterial activity was assessed from the minimal inhibitory concentration for the antibiotics alone or in combination with EDTA-tromethamine. EDTA-tromethamine potentiated the antibacterial activity of ampicillin, chloramphenicol, oxytetracycline and streptomycin up to four-fold. There were no significant or consistent synergistic effects with nalidixic acid or sulphadimethoxine.

引用

页码：77 / 84

页数：8

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