RESULTS OF A RANDOMIZED CLINICAL-TRIAL COMPARING 2 RADIATION SCHEDULES IN THE PALLIATIVE TREATMENT OF BRAIN METASTASES

被引：85

作者：

HAIEMEDER, C

PELLAECOSSET, B

LAPLANCHE, A

LAGRANGE, JL

TUCHAIS, C

NOGUES, C

ARRIAGADA, R

机构：

[1] INST GUSTAVE ROUSSY,DEPT RADIOTHERAPY,F-94805 VILLEJUIF,FRANCE

[2] INST GUSTAVE ROUSSY,DEPT STAT,F-94805 VILLEJUIF,FRANCE

[3] CTR ANTOINE LACASSAGNE,DEPT RADIOTHERAPY,F-06054 NICE,FRANCE

[4] CTR PAUL PAPIN,DEPT RADIOTHERAPY,ANGERS,FRANCE

来源：

RADIOTHERAPY AND ONCOLOGY | 1993年 / 26卷 / 02期

关键词：

BRAIN METASTASIS; RADIOTHERAPY; RANDOMIZED TRIAL;

D O I：

10.1016/0167-8140(93)90091-L

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In 216 patients with brain metastases two schedules of brain irradiation were compared in a randomized trial: one course of 18 Gy/3 fractions/3 days versus the same fractionation followed by a second course of radiotherapy with a one-month time interval. The second course was identical to the first one or delivered 25 Gy/10 fractions/14 days. No difference in overall survival, nor in the neurologic response or in the incidence of complications was demonstrated. Two clinical factors appeared to be prognostic of the overall survival: the presence of multiple brain metastases and the presence of extracerebral metastases.

引用

页码：111 / 116

页数：6

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