CIRCULATING ICAM-1 LEVELS IN SERUM OF UVEITIS PATIENTS

被引：27

作者：

AROCKENMETTINGER, E ^{[1
]}

STEURERGEORGIEW, L ^{[1
]}

STEURER, M ^{[1
]}

HUBERSPITZY, V ^{[1
]}

HOELZL, E ^{[1
]}

GRABNER, G ^{[1
]}

KUCHAR, A ^{[1
]}

机构：

[1] UNIV VIENNA, DEPT EARS NOSE & THROAT 2, A-1090 VIENNA, AUSTRIA

来源：

CURRENT EYE RESEARCH | 1992年 / 11卷

关键词：

D O I：

10.3109/02713689208999527

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Intercellular Adhesion Molecule-1 (ICAM-1) is a cytokine-inducible adhesion molecule expressed on cells of multiple lineages at sites of inflammation. Recently a truncated form of ICAM-1 has been discovered to be circulating in serum. This study reports on circulating serum (cICAM-1) levels in 132 uveitis patients (HLA-B 27 pos. acute anterior uveitis (AAU); HLA-B27 neg. anterior uveitis (AU); intermediate uveitis (IU); heterochromic cyclitis Fuchs' (HCF); sarcoidosis; Toxoplasmosis). Measurement of circulating ICAM-1 serum levels was performed using a monoclonal antibody based ELISA, with healthy blood donors serving as the control group. Applying multiple variance analysis and the Student Newmann-Keuls test we found a statistically significant elevation of serum cICAM-1 level in the HLA-B 27 neg. AU group (n:31), in the IU group (n:25) and in patients with sarcoidosis (n:18). Serum levels of HLA-B27 pos. AAU patients, patients with HCF and patients suffering from ocular toxoplasmosis did not differ significantly from levels of the control group.

引用

页码：161 / 166

页数：6

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