EFFECTS OF CARVEDILOL ON SERUM-LIPIDS IN HYPERTENSIVE AND NORMOTENSIVE SUBJECTS

The effects of carvedilol (an α · β-blocker) on lipid metabolism were assessed in addition to its hypotensive effect. The subjects were 18 men and 18 women, 20 with hypertension and 16 normotensives with other conditions requiring carvedilol treatment. They were aged from 31 to 79 years and were given a daily dose of 5-20 mg carvedilol (average, 9.7 mg/day) for 12 weeks. Significant falls were seen in blood pressure and heart rate after 12 weeks in the hypertensive subjects (mean ± SE) (systolic: from 164 ± 2 to 141 ± 2 mm Hg, P < 0.001; diastolic: from 98 ± 1 to 85 ± 2 mm Hg, P < 0.001; heart rate: from 71 to 65 beats/min, P < 0.001). Smaller changes in blood pressure and heart rate were seen in the normotensive subjects, with the fall in systolic pressure being significant (from 143±3 to 135 ± 2 mm Hg, P < 0.01). There were no significant changes in the overall serum total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and phospholipid levels. In the subgroup with a pretreatment serum triglyceride level of > 150 mg/dl, a significant fall of 52.1 mg/dl was seen (P < 0.05). Lipoprotein analysis showed a significant fall in α-lipoprotein levels (P < 0.05). The atherogenic index did not change significantly, and it was concluded that carvedilol was an effective antihypertensive agent that produced no adverse effects and possibly had beneficial effects on lipid metabolism. © 1990 Springer-Verlag.