NEUTROPHIL INFLUX INTO AN INFLAMMATORY SITE INHIBITED BY A SOLUBLE HOMING RECEPTOR-IGG CHIMERA

被引:291
作者
WATSON, SR
FENNIE, C
LASKY, LA
机构
[1] Department of Immunobiology, Genentech, South San Francisco, CA 94080
关键词
D O I
10.1038/349164a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Neutrophil-mediated inflammation is involved in a number of human clinical manifestations, including the adult respiratory distress syndrome, multi-organ failure and reperfusion injury 1. One way of inhibiting this type of inflammatory response would be to block competitively the adhesive interactions between neutrophils and the endothelium adjacent to the inflamed region 2. The lectin-containing 3,4 murine adhesion molecule gp90MET, the homing receptor, is found on all leukocytic cells, including neutrophils. 5 MEL 14, a monoclonal antibody directed against this adhesion molecule, blocks lymphocyte traffic to lymph nodes 6 and extravasation of neutrophils from blood to inflammatory sites 7. Here we show that administration to mice of a soluble immunoglobulin chimaera containing the murine homing receptor extracellular domain significantly decreases the number of neutrophils that migrate to the peritoneum in response to the inflammatory irritant thioglycollate. These results indicate that soluble forms of a single type of adhesion molecule, the homing receptor, could be clinically effective compounds for the inhibition of neutrophil-mediated inflammation.
引用
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页码:164 / 166
页数:3
相关论文
共 23 条
  • [1] ARFORS KE, 1987, BLOOD, V69, P338
  • [2] ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 - AN INDUCIBLE RECEPTOR FOR NEUTROPHILS RELATED TO COMPLEMENT REGULATORY PROTEINS AND LECTINS
    BEVILACQUA, MP
    STENGELIN, S
    GIMBRONE, MA
    SEED, B
    [J]. SCIENCE, 1989, 243 (4895) : 1160 - 1165
  • [3] BOWEN B, 1990, J CELL BIOL, V110, P421
  • [4] DESIGNING CD4 IMMUNOADHESINS FOR AIDS THERAPY
    CAPON, DJ
    CHAMOW, SM
    MORDENTI, J
    MARSTERS, SA
    GREGORY, T
    MITSUYA, H
    BYRN, RA
    LUCAS, C
    WURM, FM
    GROOPMAN, JE
    BRODER, S
    SMITH, DH
    [J]. NATURE, 1989, 337 (6207) : 525 - 531
  • [5] COSIMI AB, 1990, J IMMUNOL, V144, P4604
  • [6] REGULATION OF ALLOREACTIVITY INVIVO BY A SOLUBLE FORM OF THE INTERLEUKIN-1 RECEPTOR
    FANSLOW, WC
    SIMS, JE
    SASSENFELD, H
    MORRISSEY, PJ
    GILLIS, S
    DOWER, SK
    WIDMER, MB
    [J]. SCIENCE, 1990, 248 (4956) : 739 - 742
  • [7] FISCHER A, 1986, LANCET, V2, P1058
  • [8] LYMPHOCYTE HOMING RECEPTORS
    GALLATIN, M
    STJOHN, TP
    SIEGELMAN, M
    REICHERT, R
    BUTCHER, EC
    WEISSMAN, IL
    [J]. CELL, 1986, 44 (05) : 673 - 680
  • [9] A CELL-SURFACE MOLECULE INVOLVED IN ORGAN-SPECIFIC HOMING OF LYMPHOCYTES
    GALLATIN, WM
    WEISSMAN, IL
    BUTCHER, EC
    [J]. NATURE, 1983, 304 (5921) : 30 - 34
  • [10] Goldstein I., 1988, INFLAMMATION BASIC P