HIV-1 PROTEASE CLEAVES ACTIN DURING ACUTE INFECTION OF HUMAN LYMPHOCYTES-T

被引：43

作者：

ADAMS, LD ^{[1
]}

TOMASSELLI, AG ^{[1
]}

ROBBINS, P ^{[1
]}

MOSS, B ^{[1
]}

HEINRIKSON, RL ^{[1
]}

机构：

[1] NIAID,VIRAL DIS LAB,BETHESDA,MD 20892

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1992年 / 8卷 / 02期

关键词：

D O I：

10.1089/aid.1992.8.291

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Actin, one of the most abundant proteins of the cell, is hydrolyzed by the human immunodeficiency virus type 1 (HIV-1) protease during acute infection of cultured human T lymphocytes. The actin fragments produced during the course of infection are identical to those obtained by recombinant HIV-1 protease digests of (1) a lysate from uninfected T lymphocytes and (2) globular actin itself. Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis.

引用

页码：291 / 295

页数：5

共 28 条

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