SUSTAINED HYPERTENSION IN THE RAT INDUCED BY CHRONIC BLOCKADE OF NITRIC-OXIDE PRODUCTION

被引：87

作者：

JOHNSON, RA ^{[1
]}

FREEMAN, RH ^{[1
]}

机构：

[1] UNIV MISSOURI,SCH MED,DEPT WESTERN REG RES LAB,ROOM MA415,MED SCI BLDG,COLUMBIA,MO 65212

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1992年 / 5卷 / 12期

关键词：

NITRIC OXIDE SYNTHESIS; SODIUM EXCRETION; PLASMA RENIN ACTIVITY; NW-NITRO-L-ARGININE METHYL ESTER;

D O I：

10.1093/ajh/5.12.919

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

It is well established that acute systemic blockage of L-arginine conversion to nitric oxide by N(W)-nitro-L-arginine methyl ester (L-NAME) and other substituted analogs of L-arginine produces vasoconstriction and elevates the blood pressure. The present study in rats reports that chronic L-NAME injections (185 mumol/L/kg body weight, intraperitoneally; every 12 h) for 4 days produces sustained arterial hypertension which is fully and rapidly reversed by acute administration of exceSS L-arginine. The magnitude of the hypertension is not different between L-NAME treated rats fed normal or high sodium diets. The results from this simple experimental model suggest that chronic blockade of nitric oxide synthesis results in sustained arterial hypertension that is not enhanced by sodium loading.

引用

页码：919 / 922

页数：4

共 14 条

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