CHRONIC FLUOXETINE TREATMENT REDUCES HYPOTHALAMIC VASOPRESSIN SECRETION INVITRO

被引：49

作者：

ALTEMUS, M ^{[1
]}

CIZZA, G ^{[1
]}

GOLD, PW ^{[1
]}

机构：

[1] NIMH, DIV INTRAMURAL RES PROGRAMS, CLIN NEUROENDOCRINOL BRANCH, BETHESDA, MD 20892 USA

来源：

BRAIN RESEARCH | 1992年 / 593卷 / 02期

关键词：

VASOPRESSIN; FLUOXETINE; HYPOTHALAMUS; OBSESSIVE-COMPULSIVE DISORDER;

D O I：

10.1016/0006-8993(92)91326-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Patients with obsessive-compulsive disorder (OCD) hypersecrete the arousal producing neurohormone arginine vasopressin (AVP) into the cerebrospinal fluid and plasma. Because OCD responds preferentially to potent serotonin uptake inhibitors, we compared the effect of chronic fluoxetine treatment to that of other antidepressants (trazodone and desipramine) on AVP release from rat hypothalamic organ culture and showed that only fluoxetine significantly reduced in vitro AVP release.

引用

页码：311 / 313

页数：3

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