CARBAMAZEPINE POISONING IN CHILDREN

被引:17
作者
MACNAB, AJ
BIRCH, P
MACREADY, J
机构
[1] Department of Pediatrics, British Columbia Children’s Hospital
[2] Department of Medical Genetics, University of British Columbia
关键词
CARBAMAZEPINE; POISONING; OVERDOSE;
D O I
10.1097/00006565-199308000-00003
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Carbamazepine poisoning in children remains a significant problem for the emergency physician. We report 16 cases of toxicity at British Columbia Children's Hospital and discuss presenting symptoms, treatment, and hospital course. Pharmacology, drug interactions resulting in carbamazepine toxicity, and treatment guidelines are summarized.
引用
收藏
页码:195 / 198
页数:4
相关论文
共 22 条
[1]  
Weaver D.F., Camfield P., Frazer A., Massive carbamazepine overdose: Clinical and pharmacological observations in five episodes, Neurology, 38, pp. 755-759, (1988)
[2]  
Sethna M., Solomon G., Cedarbaum J., Et al., Successful treatment of massive carbamazepine overdose, Epilepsia, 30, pp. 71-73, (1989)
[3]  
Spiller H.A., Krenzelok E.P., Cookson E., Carbamazepine overdose: A prospective study of serum levels and toxicity, Clin Toxicol, 28, pp. 445-458, (1990)
[4]  
Macnab A.J., Robinson J.L., Adderly R.J., Et al., Heart block secondary to erythromycin-induced carbamazepine toxicity, Pediatrics, 80, pp. 951-952, (1987)
[5]  
Uziel Y., Pomeranz A., Jedeikin R., Et al., Acute carbamazepine poisoning and hyponatremia, Child Nephrol Urol 1988-89, 9
[6]  
Rubenstein K.E., Schneider R.S., Ullman E.F., Homogenous enzyme immunoassay. A new immunological technique, Biochem Biophys Res Commun, 47, pp. 846-851, (1972)
[7]  
Post R.M., Time course of clinical effects of carbamazepine: Implications for mechanisms of action, J Clin Psychiatry, 49, suppl, pp. 35-46, (1988)
[8]  
Cochran E.B., Massey K.L., Phelps S.J., A rapid, noninstrumented whole blood carbamazepine assay for pediatric patients, J Pediatr, 116, pp. 307-310, (1990)
[9]  
Micromedex Inc, 1991, (1991)
[10]  
Pippenger C.E., Clinically significant carbamazepine drug interactions: An overview, Epilepsia, 28, suppl, pp. S71-S76, (1987)