ISOLATION OF A HIGHLY FUNCTIONALIZED TROGER BASE DERIVATIVE VIA A NOVEL REACTION

被引:33
作者
BECKER, DP
FINNEGAN, PM
COLLINS, PW
机构
[1] Searle Research and Development, Skokie, IL 60077
关键词
D O I
10.1016/S0040-4039(00)91955-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Heating a solution of methyl 5-chloro-4-[(ethoxyoxoacctyl)amino]-2-methoxybenz-oate 3 in DMSO gave rise to the formation of the highly substituted Troger's base derivative dimethyl 4,10-dichloro-1,7-dimethoxy-6H,12H-5,11-methano-dibenzo[b,f][1,5]diazocine-2,8-dicarboxylate 4 as well as methyl 8-chloro-5-methoxy-6-quinolinecarboxylate 5.
引用
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页码:1889 / 1892
页数:4
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