FECL3-CATALYZED CONJUGATE ADDITION OF SECONDARY-AMINES, IMIDAZOLE AND PYRAZOLE TO METHYL 2-ACETAMIDOACRYLATE - PREPARATION OF BETA-DIALKYLAMINO-ALPHA-ALANINE AND BETA-(N-HETEROARYL)-ALPHA-ALANINE DERIVATIVES

被引：65

作者：

PEREZ, M ^{[1
]}

PLEIXATS, R ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,DEPT CHEM,E-08193 BARCELONA,SPAIN

来源：

TETRAHEDRON | 1995年 / 51卷 / 30期

关键词：

D O I：

10.1016/0040-4020(95)00446-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Dialkylamino-alpha-alanine and beta-(N-heteroaryl)-alpha-alanine derivatives are obtained by conjugate addition of nitrogen based nucleophiles (cyclic and acyclic secondary amines, imidazole and pirazole) to methyl 2-acetamidoacrylate, 1, under iron(III) chloride catalysis.

引用

页码：8355 / 8362

页数：8

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