THE START GENE CDC28 AND THE GENETIC STABILITY OF YEAST

被引:34
作者
DEVIN, AB
PROSVIROVA, TY
PESHEKHONOV, VT
CHEPURNAYA, OV
SMIRNOVA, ME
KOLTOVAYA, NA
TROITSKAYA, EN
ARMAN, IP
机构
[1] DUBNA JOINT NUCL RES INST, DUBNA 141980, USSR
[2] BP KONSTANTINOV NUCL PHYS INST, GATCHINA 188350, USSR
[3] AN BAKH BIOCHEM INST, MOSCOW 117071, USSR
关键词
CDC28; gene; cell cycle regulation; chromosome loss; plasmid maintenance; rho[!sup]−[!/sup] mutation; Saccharomyces cerevisiae;
D O I
10.1002/yea.320060308
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The cdc28‐srm mutation in Saccheromyces cerevisiae decreases spontaneous and induced mitochondrial rhomutability and the mitotic stability of native chromosomes and recombinant circular minichromosomes. The effects of cdc28‐srm on the genetic stability of cells support the hypothesis that links cell cycle regulation in yeast to changes in chromatin organization dependent on the start gene CDC28 (Hayles and Nurse, 1986). Copyright © 1990 John Wiley & Sons Ltd.
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页码:231 / 243
页数:13
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