THE GASTROINTESTINAL TRANSIT OF A CONTROLLED RELEASE FORMULATION OF INDOMETHACIN

被引：17

作者：

DAVIS, SS

KHOSLA, R

WILSON, CG

WASHINGTON, N

LESLIE, ST

MALKOWSKA, S

机构：

[1] NAPP RES CTR, SCI PK, CAMBRIDGE, ENGLAND

[2] UNIV NOTTINGHAM, SCH MED, DEPT PHARMACEUT SCI, NOTTINGHAM NG7 2RD, ENGLAND

[3] UNIV NOTTINGHAM, SCH MED, DEPT PHYSIOL & PHARMACOL, NOTTINGHAM NG7 2RD, ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 60卷 / 03期

关键词：

Controlled release formulation; Gastrointestinal transit; Indomethacin;

D O I：

10.1016/0378-5173(90)90072-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The gastrointestinal transit of a controlled release indomethacin tablet has been evaluated in vivo in a group of six fasted and fed subjects using the technique of gamma-scintigraphy. The product was similar in its gastrointestinal transit behaviour to other pharmaceutical dosage forms; emptying of the tablet from the stomach was slowed by the presence of food but transit through the small intestine was not affected by feeding conditions. In vivo the tablet underwent a process of gradual dissolution and diffusion followed by complete dispersion. The bioavailability of indomethacin from this preparation was not affected by the presence of food. © 1990.

引用

页码：191 / 196

页数：6

共 11 条

[1]

ALVAN G, 1975, CLIN PHARMACOL THER, V18, P364

[2] CRITICAL EVALUATION OF THE POTENTIAL ERROR IN PHARMACOKINETIC STUDIES OF USING THE LINEAR TRAPEZOIDAL RULE METHOD FOR THE CALCULATION OF THE AREA UNDER THE PLASMA LEVEL TIME CURVE [J].