OPTIMIZATION OF MULTISTAGE TESTING TIMES AND CRITICAL-VALUES IN CLINICAL-TRIALS

被引：14

作者：

BRITTAIN, EH

BAILEY, KR

机构：

[1] NHLBI,BIOSTAT RES BRANCH,BETHESDA,MD 20892

[2] MAYO CLIN,MED RES STAT,ROCHESTER,MN 55901

来源：

BIOMETRICS | 1993年 / 49卷 / 03期

关键词：

CLINICAL TRIALS; INTERIM ANALYSES;

D O I：

10.2307/2532197

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Optimal critical values and times of intermediate testing points are determined to minimize expected sample size in a variety of situations. Two-stage and three-stage models are considered for a variety of values of power. We investigate the robustness of the optimality parameters.

引用

页码：763 / 772

页数：10

共 8 条

[1] 2-STAGE CLINICAL-TRIAL STOPPING RULES [J].