OPTIMIZATION OF MULTISTAGE TESTING TIMES AND CRITICAL-VALUES IN CLINICAL-TRIALS

被引:14
作者
BRITTAIN, EH
BAILEY, KR
机构
[1] NHLBI,BIOSTAT RES BRANCH,BETHESDA,MD 20892
[2] MAYO CLIN,MED RES STAT,ROCHESTER,MN 55901
关键词
CLINICAL TRIALS; INTERIM ANALYSES;
D O I
10.2307/2532197
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Optimal critical values and times of intermediate testing points are determined to minimize expected sample size in a variety of situations. Two-stage and three-stage models are considered for a variety of values of power. We investigate the robustness of the optimality parameters.
引用
收藏
页码:763 / 772
页数:10
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