SPECIES-DIFFERENCE IN THE MODULATORY EFFECT OF KAPPA-AGONIST ON 5-HT RELEASE FROM GROUND-SQUIRREL AND RAT HIPPOCAMPUS

被引：11

作者：

CUI, Y ^{[1
]}

LEE, TF ^{[1
]}

WANG, LCH ^{[1
]}

机构：

[1] UNIV ALBERTA, DEPT ZOOL, EDMONTON T6G 2E9, AB, CANADA

来源：

NEUROSCIENCE LETTERS | 1994年 / 175卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

OPIOID; KAPPA OPIOID RECEPTOR; U50488; SEROTONIN RELEASE; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(94)91095-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inclusion of the re agonist U50488 in the perifusion medium enhanced K+-stimulated 5-HT release from ground squirrel hippocampal slices, but reduced 5-HT outflow in both young and old rats' hippocampal slices. The stimulatory effect of U50488 on 5-HT release from ground squirrel hippocampus was not significantly attenuated by the non-specific opioid antagonist naloxone (10(-5) M), but was completely reversed by the specific kappa antagonist nor-BNI (10(-6) M), and the voltage-dependent sodium channel blocker TTX (10(-6) M). In contrast, the inhibitory effect of U50488 on 5-HT release from the young rat hippocampus was attenuated by naloxone (10(-6) M), but not by nor-BNI (10(-6) M) or TTX (10(-6) M). These results illustrate a significant species difference in the modulatory effect of opioids on neurotransmitter release in the hippocampus.

引用

页码：126 / 128

页数：3

共 17 条

[1]

CHANG KJ, 1979, MOL PHARMACOL, V16, P91

[2] THE MODULATORY EFFECTS OF MU-OPIOID AND KAPPA-OPIOID AGONISTS ON 5-HT RELEASE FROM HIPPOCAMPAL AND HYPOTHALAMIC SLICES OF EUTHERMIC AND HIBERNATING GROUND-SQUIRRELS [J].