PERIPHERAL MYELIN PROTEIN-22 - FACTS AND HYPOTHESES

被引:92
作者
SUTER, U
SNIPES, GJ
机构
[1] STANFORD UNIV,SCH MED,DEPT NEUROBIOL,STANFORD,CA 94305
[2] STANFORD UNIV,SCH MED,DEPT PATHOL NEUROPATHOL,STANFORD,CA 94305
关键词
MYELIN; TREMBLER; CHARCOT-MARIE-TOOTH DISEASE; HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES; PERIPHERAL NEUROPATHY; PMP22; PO; PLP; DM20; CONNEXIN; 32;
D O I
10.1002/jnr.490400202
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Mutations affecting the peripheral myelin protein 22 (PMP22) gene are associated with inherited motor and sensory neuropathies in mouse (Trembler and Trembler-J) and human (Charcot-Marie-Tooth disease type 1A and Dejerine-Sottas syndrome). Although genetic studies have established a critical role of PMP22 in the formation and/or maintenance of myelin in the peripheral nervous system, the biological function of PMP22 in myelin and in non-myelin forming cells remains largely enigmatic. In this Mini-Review, we will summarize the current knowledge about PMP22 and discuss its hypothetical function(s) in a broad context. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:145 / 151
页数:7
相关论文
共 59 条
  • [1] CONNEXIN MUTATIONS IN X-LINKED CHARCOT-MARIE-TOOTH DISEASE
    BERGOFFEN, J
    SCHERER, SS
    WANG, S
    SCOTT, MO
    BONE, LJ
    PAUL, DL
    CHEN, K
    LENSCH, MW
    CHANCE, PF
    FISCHBECK, KH
    [J]. SCIENCE, 1993, 262 (5142) : 2039 - 2042
  • [2] DIFFERENTIAL EXPRESSION OF 2 MESSENGER-RNA SPECIES INDICATES A DUAL FUNCTION OF PERIPHERAL MYELIN PROTEIN PMP22 IN CELL-GROWTH AND MYELINATION
    BOSSE, F
    ZOIDL, G
    WILMS, S
    GILLEN, CP
    KUHN, HG
    MULLER, HW
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 37 (04) : 529 - 537
  • [3] BRUZZONE R, 1994, IN PRESS NEURON
  • [4] DNA DELETION ASSOCIATED WITH HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES
    CHANCE, PF
    ALDERSON, MK
    LEPPIG, KA
    LENSCH, MW
    MATSUNAMI, N
    SMITH, B
    SWANSON, PD
    ODELBERG, SJ
    DISTECHE, CM
    BIRD, TD
    [J]. CELL, 1993, 72 (01) : 143 - 151
  • [5] CHANCE PF, 1994, HUM MOL GENET, V3, P323
  • [6] AN INTERSTITIAL DUPLICATION OF THE X-CHROMOSOME IN A MALE ALLOWS PHYSICAL FINE MAPPING OF PROBES FROM THE XQ13-Q22 REGION
    CREMERS, FPM
    PFEIFFER, RA
    VANDEPOL, TJR
    HOFKER, MH
    KRUSE, TA
    WIERINGA, B
    ROPERS, HH
    [J]. HUMAN GENETICS, 1987, 77 (01) : 23 - 27
  • [7] DELEON M, 1991, J NEUROSCI RES, V29, P437
  • [8] SR13/PMP-22 EXPRESSION IN RAT NERVOUS-SYSTEM, IN PC12 CELLS, AND C6 GLIAL-CELL LINES
    DELEON, M
    NAHIN, RL
    MENDOZA, ME
    RUDA, MA
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 38 (02) : 167 - 181
  • [9] GAP-JUNCTIONS IN THE BRAIN - WHERE, WHAT TYPE, HOW MANY AND WHY
    DERMIETZEL, R
    SPRAY, DC
    [J]. TRENDS IN NEUROSCIENCES, 1993, 16 (05) : 186 - 192
  • [10] Dyck PJ, 1994, PERIPHERAL NEUROPATH, P1094