A PARTIAL PHARMACOPHORE FOR THE PLATELET-ACTIVATING-FACTOR (PAF) RECEPTOR

被引：25

作者：

HODGKIN, EE

MILLER, A

WHITTAKER, M

机构：

[1] British Bio-technology Ltd., Oxford, OX4 5LY, Watlington Road

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81205-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A partial pharmacophore for the platelet activating factor receptor has been generated by a molecular modelling comparison of five heterocyclic sp2 nitrogen PAF antagonists using a Monte Carlo 'Boltzmann Jump' technique. This pharmacophore defines the relative spatial orientation of the plane of the heterocyclic ring, the sp2 nitrogen, a carbonyl/sulphonyl pharmacophoric group and a sulphur atom.

引用

页码：597 / 602

页数：6

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