EFFECTS OF TOPICAL MITOMYCIN-C ON PRIMARY TRABECULECTOMIES AND COMBINED PROCEDURES

The charts were reviewed of all patients who underwent primary trabeculectomies (group 1) or combined procedures (phacoemulsification+intraocular lens implantation+trabeculectomy - group 2) and received intraoperative mitomycin C (0.4 mg/ml) between 1991 and 1992 at Wills Eye Hospital. A total of 54 eyes of 54 patients were included: 39 in group 1 and 15 in group 2. Intraocular pressure was controlled successfully in 97.4% of eyes in group 1 (mean follow up 6-7 months), and in 93.3% in group 2 (mean follow up 6.8 months). Main complications included choroidal detachment (n=15), shallow anterior chamber (n=9), cataract formation (n=8), and hypotony maculopathy (n=3). The use of mitomycin C in primary trabeculectomies and combined procedures is associated with high success rates. However, it may be associated with unacceptable risks of vision threatening complications related to excessive filtration.