INDOLE 3-ACETIC ACIDS AND HETERO ANALOGS BY ONE-POT SYNTHESIS INCLUDING HECK CYCLIZATION

被引:41
作者
WENSBO, D
ANNBY, U
GRONOWITZ, S
机构
[1] CTR CHEM,DEPT ORGAN CHEM 1,S-22100 LUND,SWEDEN
[2] SYNTHELEC AB,IDEON,S-22370 LUND,SWEDEN
关键词
D O I
10.1016/0040-4020(95)00601-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Bz-substituted indole-3-acetic acid ethyl esters (14e-g) and heteroanalogues, i.e. thienopyrroles (14a, c) and selenolopyrrole (14d), were prepared starting from N-BOC protected o-iodo aryl amines. Allylation with ethyl 4-bromocrotonate, followed by palladium-catalysed ring closure in a one pot reaction, yielded N-BOC protected indoles (13e-g), thienopyrroles (13a-c), and selenolopyrrole (13d). The BOC group was readily removed thermally after adsorption on silica. Oxothienopyrroles (11a-c) were similarly prepared.
引用
收藏
页码:10323 / 10342
页数:20
相关论文
共 53 条