INDOLE 3-ACETIC ACIDS AND HETERO ANALOGS BY ONE-POT SYNTHESIS INCLUDING HECK CYCLIZATION

被引：41

作者：

WENSBO, D

ANNBY, U

GRONOWITZ, S

机构：

[1] CTR CHEM,DEPT ORGAN CHEM 1,S-22100 LUND,SWEDEN

[2] SYNTHELEC AB,IDEON,S-22370 LUND,SWEDEN

来源：

TETRAHEDRON | 1995年 / 51卷 / 37期

关键词：

D O I：

10.1016/0040-4020(95)00601-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bz-substituted indole-3-acetic acid ethyl esters (14e-g) and heteroanalogues, i.e. thienopyrroles (14a, c) and selenolopyrrole (14d), were prepared starting from N-BOC protected o-iodo aryl amines. Allylation with ethyl 4-bromocrotonate, followed by palladium-catalysed ring closure in a one pot reaction, yielded N-BOC protected indoles (13e-g), thienopyrroles (13a-c), and selenolopyrrole (13d). The BOC group was readily removed thermally after adsorption on silica. Oxothienopyrroles (11a-c) were similarly prepared.

引用

页码：10323 / 10342

页数：20

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