FREE RADICAL-DEPENDENT SUPPRESSION OF GROWTH OF MOUSE MYELOMA CELLS BY ALPHA-LINOLENIC AND EICOSAPENTAENOIC ACIDS IN-VITRO

被引：47

作者：

KUMAR, GS ^{[1
]}

DAS, UN ^{[1
]}

机构：

[1] NIZAMS INST MED SCI, DEPT MED, HYDERABAD 500482, ANDHRA PRADESH, INDIA

来源：

CANCER LETTERS | 1995年 / 92卷 / 01期

关键词：

MOUSE MYELOMA CELLS; ALPHA-LINOLENIC ACID; EICOSAPENTAENOIC ACID; CYTOTOXICITY; FREE RADICALS; LIPID PEROXIDES; ANTIOXIDANT ENZYMES;

D O I：

10.1016/0304-3835(95)03753-J

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) exhibited potent cytotoxic action on SP 2/0 mouse myeloma cells in vitro. Both SOD and vitamin E could inhibit the action of ALA and EPA indicating a role for reactive oxygen species and lipid peroxides. In addition, both ALA and EPA enhanced the formation of superoxide anion, hydrogen peroxide and lipid peroxides, and caused a reduction in the levels of antioxidant enzymes: SOD, catalase and glutathione peroxidase and induced significant damage to DNA in SP 2/0 cells. Thus, ALA and EPA inhibit antioxidant defenses of the cell and damage the DNA, which can ultimately lead to tumor cell lysis.

引用

页码：27 / 38

页数：12

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