Anticipation in Swedish families with schizophrenia

被引:19
作者
Chotai, J [1 ]
Engstrom, C [1 ]
Ekholm, B [1 ]
Berg, MLJ [1 ]
Adolfsson, R [1 ]
Nylander, PO [1 ]
机构
[1] UMEA UNIV, DEPT PSYCHIAT, S-90185 UMEA, SWEDEN
关键词
anticipation; genetics; schizophrenia;
D O I
10.1097/00041444-199524000-00006
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Nineteen parent-offspring pairs obtained from 14 two-generation families with available medical records and diagnosis of schizophrenia were studied to compare the ages of onset of the parent generation with those of the offspring generation. The mean age of onset for the parent generation was 37.3 +/- 6.0 years and for the offspring generation was 20.8 +/- 4.4. The mean difference was thus 16.5 +/- 6.2, suggesting the occurrence of anticipation in schizophrenia (p < 0.001). Although some ascertainment biases (like reduced fertility in early-onset parents or early detection of symptoms in offsprings of affected parents) may partially contribute to the occurrence of anticipation, this study replicates recent reports of anticipation in several neuropsychiatric disorders, some of which have been shown to be associated with unstable expansions of trinucleotide repeats in the genomic DNA.
引用
收藏
页码:181 / 186
页数:6
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