RISK-FACTORS FOR SPONTANEOUS-ABORTION - A CASE-CONTROL STUDY IN FRANCE

被引：49

作者：

COSTE, J

JOBSPIRA, N

FERNANDEZ, H

机构：

[1] INSERM U.292, Hôpital de Biêtre, 94275 Le Kremlin-Bicêtre Cedex, 78, rue du Général Leclerc

[2] INSERM U. 187, Maternité Antoine Béclère, 92140 Clamart, 157, rue Porte de Trivaux

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 09期

关键词：

SPONTANEOUS ABORTION; RISK FACTORS;

D O I：

10.1093/oxfordjournals.humrep.a137535

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A case-control study was conducted in seven maternity hospitals in the Paris area in 1988 to evaluate the role of several risk factors in spontaneous abortion. A total of 279 cases and 279 controls were compared for socio-demographic characteristics, reproductive history and for conditions of conception. Prior fetal losses [odds ratio (OR) = 2.30 for n greater-than-or-equal-to 2; 95% confidence interval (CI) = 1.17-4.61] and maternal age at pregnancy (> 30 years) appeared to be major and independent risk factors of spontaneous abortion. Other factors associated with an increased risk of fetal loss were: geographical or ethnic origin (OR = 2.85 for North African women; 95% CI = 1.58-5.10); psychological problems at the time of conception, either related to the outcome of the pregnancy (OR = 3.08; 95% CI= 0.92-10.25) or unrelated to this outcome (OR = 3.35; 95% CI = 1.41-8.00). The following factors were not associated with spontaneous abortion: gravidity, parity, prior induced abortion, prior sexually transmitted diseases and Chlamydia trachomatis serology, menstrual cycle abnormalities, induced conception cycle and in-vitro fertilization, cigarette smoking, current or past use of combined oestrogen/progestagen pill or intra-uterine device. These findings confirm the importance of two risk factors for fetal loss: maternal age and number of prior spontaneous abortions. Two risk factors, ethnic origin and psychological problems at the time of conception are also identified, which require further study.

引用

页码：1332 / 1337

页数：6

共 25 条

[1] Breslow N.E., Day N.E., Statistical Methods in Cancer Research, Vol. I: The Analysis of Case-Control Studies, International Agency for Research on Cancer, Lyon, France, 32, (1980)
[2] Christiansen O.B., Mathiesen O., Grunnet N., Jersild C., Is there a common genetic background for pre-eclampsia and recurrent spontaneous abortions?, Lancet, 1, pp. 361-362, (1990)
[3] Coste J., Job-Spira N., Fernandez H., Increased risk of ectopic pregnancy with cigarette smoking, Am. J. Public Health, 81, pp. 199-201, (1991)
[4] Coste J., Job-Spira N., Fernandez H., Papiemik E., Spira A., Risk factors of ectopic pregnancy: A case-control study in France, with special focus on infectious factors, Am. J. Epidemiol., 133, pp. 839-849, (1991)
[5] Edo M.A., Otero H.R., Caro L., The influence of consanguinity on fertility and infant mortality in Sanab ria (Zamora, Spain). Biol, Soc., 2, pp. 129-134, (1985)
[6] Edwards R.G., Causes of early embryonic loss in human pregnancy. Hum, Reprod., 1, pp. 185-198, (1986)
[7] Hall R.C.W., Beresford T.P., Quinones J.E., Grief following spontaneous abortion, Psychiat. Clin. North Am, 10, pp. 405-420, (1987)
[8] Harlap S., Shiono P.H., Ramcharan S., A life table of spontaneous abortion and the effects of age, parity, and other variables, Academic Press, New York, pp. 145-158, (1980)
[9] Hemminki K., Nienti M.L., Saloniemi I., Vaino H., Hetnminki E., Spontaneous abortion by occupation and social class in Finland, Int. J. Epidemiol., 9, pp. 149-153, (1980)
[10] Himmelberger D.U., Brown B.W., Cohen E.N., Cigarette smoking during pregnancy and the occurrence of spontaneous abortion and congenital abnormality, Am. J. Epidemiol, 108, pp. 470-479, (1978)

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