THE EFFECT OF COMBINATIONS OF AMPLIGEN AND ZIDOVUDINE OR DIDEOXYINOSINE AGAINST HUMAN IMMUNODEFICIENCY VIRUSES INVITRO

被引：23

作者：

OMARRO, SD

ARMSTRONG, JA

ASUNCION, C

GUEVERRA, L

HO, M

机构：

[1] UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT INFECT DIS & MICROBIOL,A427 CRABTREE HALL,PITTSBURGH,PA 15261

[2] UNIV PITTSBURGH,AIDS CLIN TRIALS UNIT,PITTSBURGH,PA 15261

[3] UNIV PITTSBURGH,SCH MED,DEPT MED,PITTSBURGH,PA 15261

[4] UNIV PITTSBURGH,SCH MED,DEPT PATHOL,PITTSBURGH,PA 15261

来源：

ANTIVIRAL RESEARCH | 1992年 / 17卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HUMAN IMMUNODEFICIENCY VIRUS; AIDS; ANTIVIRAL; DRUG RESISTANCE; AZIDOTHYMIDINE; ZIDOVUDINE; DIDEOXYINOSINE;

D O I：

10.1016/0166-3542(92)90050-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The combinations of ampligen and zidovudine at ratios of 100:1, 25:1, 10:1, and 1:50 acted synergistically to reduce cytopathology caused by HIV in MT-2 cell cultures. Combination indices were less than 1 at all of these ratios representing different combinations of concentrations and at 3 effective doses (ED30, ED50, ED70). Combination of drugs which show synergism at a wide range of ratios of combinations suggest that they may be useful clinically, and that the antiviral efficacy of ZDV may be increased in combination with ampligen. Synergism was also found between ampligen and zidovudine by reduction of HIV-produced plaques in a HeLa cell line expressing CD-4 receptors. However the combination of ampligen and dideoxyinosine against HIV in MT-2 cells was only additive and not synergistic.

引用

页码：169 / 177

页数：9

共 23 条

[1]

CARTER WA, 1987, LANCET, V1, P1286

[2] STRUCTURAL REQUIREMENTS OF RIN.RCN COMPLEX FOR INDUCTION OF HUMAN INTERFERON [J].