ABNORMAL ERYTHROCYTE AND RENAL FRUSEMIDE-SENSITIVE SODIUM-TRANSPORT IN IDIOPATHIC CALCIUM NEPHROLITHIASIS

被引：18

作者：

BAGGIO, B ^{[1
]}

GAMBARO, G ^{[1
]}

MARCHINI, F ^{[1
]}

VINCENTI, M ^{[1
]}

CEOLOTTO, G ^{[1
]}

PESSINA, AC ^{[1
]}

SEMPLICINI, A ^{[1
]}

机构：

[1] UNIV PADUA POLYCLIN, DIV CLIN MED, I-35128 PADUA, ITALY

来源：

CLINICAL SCIENCE | 1994年 / 86卷 / 03期

关键词：

ERYTHROCYTE; NA+-K+-CL- COTRANSPORT; NEPHROLITHIASES; OXALATE;

D O I：

10.1042/cs0860239

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. Anomalous transmembrane anion transport has been observed in erythrocytes of patients with idiopathic calcium nephrolithiasis. 2. To verify whether cation transport is also abnormal, we investigated the frusemide-sensitive Na+ efflux from Na+-loaded erythrocytes and the natriuretic response to acute intravenous frusemide administration in calcium oxalate renal stone former. 3. Frusemide administration induced a statistically significant smaller increase in the fractional excretion of Na+ in patients than in control subjects. Abnormal kinetic properties of erythrocyte Na+-K+-2Cl(-) co-transport were observed in approximately 60% of stone formers. The K-m for Na+ of Na+-K+-2Cl(-) co-transport correlated with urinary Ca2+ excretion. 4. The abnormal kinetic properties of Na+-K+-2Cl(-) co-transport may be relevant for stone formation, hampering renal Ca2+ reabsorption in the distal nephron and determining critical physicochemical conditions for calcium/oxalate crystallization.

引用

页码：239 / 243

页数：5

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