GENTAMICIN ONCE-DAILY VERSUS THRICE-DAILY IN CHILDREN

被引:35
作者
ELHANAN, K
SIPLOVICH, L
RAZ, R
机构
[1] CENT EMEK HOSP,DEPT PEDIAT A,IL-18101 AFULA,ISRAEL
[2] CENT EMEK HOSP,DEPT PEDIAT SURG,IL-18101 AFULA,ISRAEL
[3] CENT EMEK HOSP,INFECT DIS UNIT,IL-18101 AFULA,ISRAEL
关键词
D O I
10.1093/jac/35.2.327
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Fifty children aged 3 months-16 y with Gram-negative bacterial infections, were evaluated in this open randomized study; 26 received gentamicin 4.5 mg/kg/day, once daily, and 24 received the same daily dosage, in three divided doses. The groups had similar demographic and clinical characteristics. Serum trough gentamicin concentrations were significantly lower in the od group than in the tds group, while peak concentration were significantly higher in the od group. Clinical cure was obtained in 23 of the 26 (88.8%) children who received gentamicin once daily, and in 22/24 (91%) children treated thrice daily. Microbiological cure was obtained in 10/10 (100%) and 12/13 (92%) of the evaluated cases. Nephrotoxicity was not observed but ototoxicity occurred in two children in each group. These results, although obtained from a small number of patients, showed a similar outcome in children receiving gentamicin 45 mg/kg/day whether administered once or thrice daily.
引用
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页码:327 / 332
页数:6
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