HEPARIN COFACTOR-II AND THROMBIN - HEPARIN-BINDING PROTEINS LINKING HEMOSTASIS AND INFLAMMATION

被引：15

作者：

CHURCH, FC

HOFFMAN, MR

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT MED,CHAPEL HILL,NC

[2] UNIV N CAROLINA,SCH MED,CTR THROMBOSIS & HEMOSTASIS,CHAPEL HILL,NC

[3] DUKE UNIV,MED CTR,DEPT PATHOL,VET AFFAIRS MED CTR,LAB SERV,DURHAM,NC 27705

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/1050-1738(94)90066-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

alpha-Thrombin is a trypsinlike serine proteinase involved in blood coagulation and wound-healing processes, which interacts with many different macromolecular substances. Heparin cofactor II is a serpin (serine proteinase inhibitor) superfamily member that specifically heparin cofactor II and thrombin interact with highly negatively charged glycosaminoglycans like heparin and dermatan sulfate, and they both ave leukocyte chemoattractants. The focus of this brief review is structure-function characteristics of heparin cofactor II and thrombin and their physiologic participation in uniting hemostatic and inflammatory processes.

引用

页码：140 / 146

页数：7

共 43 条

[1] THE INHIBITORY COMPLEX OF HUMAN ALPHA-1-PROTEINASE INHIBITOR AND HUMAN-LEUKOCYTE ELASTASE IS A NEUTROPHIL CHEMOATTRACTANT [J].