CYTOTOXIC ALPHA-BETA+ AND GAMMA-DELTA+ T-CELLS IN MURINE INTESTINAL EPITHELIUM

被引：85

作者：

VINEY, JL

KILSHAW, PJ

MACDONALD, TT

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT PAEDIAT GASTROENTEROL,LONDON EC1A 7BE,ENGLAND

[2] INST ANIM PHYSIOL & GENET RES,DEPT CELL BIOL,CAMBRIDGE,ENGLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 07期

关键词：

D O I：

10.1002/eji.1830200734

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Murine intraepithelial lymphocytes (IEL) consist of two main populations. Approximately half are Thy‐1+, most of which are CD3+, T cell receptor (TcR) α/β+, and the remainder are Thy‐1−, most of which are CD3+, TcR α/β (presumably TcR γ/δ+). In redirected cytotoxicity assays, TcR α/β+ IEL are potent cytotoxic effectors. Thy‐1−, CD3+, TcR α/β− IEL isolated from athymic mice are also cytotoxic. Thus, regardless of TcR usage or Thy‐1 expression, IEL are cytotoxic effectors. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

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页码：1623 / 1626

页数：4

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