INDUCTIVE POTENCY OF TCDD, TBDD AND 3 2,3,7,8-MIXED-HALOGENATED DIOXINS IN LIVER-MICROSOMES OF MALE-RATS - ENZYME KINETIC CONSIDERATIONS

被引：21

作者：

SCHULZSCHALGE, T ^{[1
]}

KOCH, E ^{[1
]}

SCHWIND, KH ^{[1
]}

HUTZINGER, O ^{[1
]}

NEUBERT, D ^{[1
]}

机构：

[1] UNIV BAYREUTH,LEHRSTUHL OKOL CHEM & GEOCHEM,W-8580 BAYREUTH,GERMANY

来源：

CHEMOSPHERE | 1991年 / 23卷 / 11-12期

关键词：

2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; 2,3,7,8-TETRABROMODIBENZO-P-DIOXIN; 2-BROMO-3,7,8-TRICHLORODIBENZO-P-DIOXIN; 2,3-DIBROMO-7,8-DICHLORODIBENZO-P-DIOXIN; 2,3,7-TRIBROMO-8-CHLORODIBENZO-P-DIOXIN; ENZYME INDUCTION; ETHOXYRESORUFIN O-DEETHYLASE; WISTAR RATS;

D O I：

10.1016/0045-6535(91)90040-K

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The enzyme inducing potency of single doses of three 2,3,7,8-substituted mixed halogenated dibenzo-p-dioxins was investigated and compared with 2,3,7,8-TCDD and 2,3,7,8-TBDD. All substances showed a quite similar potency for EROD induction. The use of a substrate concentration of 0.5-mu-M ethoxyresorufin is strongly recommended.

引用

页码：1925 / 1931

页数：7

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