A GENETIC-MAP OF 9 LOCI ON BOVINE CHROMOSOME-2

被引：24

作者：

BEEVER, JE

DA, Y

RON, M

LEWIN, HA

机构：

[1] UNIV ILLINOIS, DEPT ANIM SCI, URBANA, IL 61801 USA

[2] AGR RES ORG, VOLCANI CTR, INST ANIM SCI, IL-50250 BET DAGAN, ISRAEL

来源：

MAMMALIAN GENOME | 1994年 / 5卷 / 09期

关键词：

D O I：

10.1007/BF00354927

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A male-specific genetic linkage map of nine loci on bovine Chromosome (Chr) 2 (BTA2) was constructed from 306 offspring belonging to six paternal half-sib families. Loci studied were the structural genes for liver/bone/kidney alkaline phosphatase (ALPL), Gardner-Rasheed feline sarcoma (v-fgr) oncogene homolog (FGR), alpha-L-fucosidase 1 (FUCA1), and fibronectin 1 (FN1), and the microsatellite loci ARO28, DU17S2, DU17S3, DU17S4, and DU17S5. Genotyping was performed by restriction fragment length polymorphism (RFLP) for structural genes and polymerase chain reaction (PCR) for the microsatellites. Two genetically independent linkage groups were identified. The order of genes in the first linkage group, L31, is (ARO28-FN1)-FGR-FUCA1-ALPL, covering a map distance of 34.1 cM between terminal markers. The second linkage group, L32, consists of DU17S2-DU17S5-DU17S4-DU17S3 and is 41.3 cM in length. Genetic linkage between FN1 and FGR confirms previous physical assignment of these genes to the same synteny group. Currently, the genetic linkage of FN1 and FGR is unique to cattle and thus localizes a site of chromosomal evolution to a 22-cM interval between the two loci.

引用

页码：542 / 545

页数：4

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