AN EXPEDITIOUS SYNTHESIS OF 2-AMINO-4(3H)-OXO-5H-PYRROLO[3,2-D]PYRIMIDINE (9-DEAZAGUANINE)

被引：16

作者：

TAYLOR, EC

YOUNG, WB

WARD, CC

机构：

[1] Department of Chemistry, Princeton University Princeton

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)60633-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

9-Deazaguanine has been synthesized in five steps from 2-amino-6-methyl-5-nitro-4(3H)-pyrimidinone by a modification of the Batcho-Leimgruber indole synthesis.

引用

页码：4595 / 4598

页数：4

共 9 条

[1] CHEMISTRY OF FORMAMIDE ACETALS
ABDULLA, RF
BRINKMEYER, RS
[J]. TETRAHEDRON, 1979, 35 (14) : 1675 - 1735
[2] Batcho A.D., 1990, ORG SYNTH, VVII, P34
[3] HOSMANE RS, 1981, SYNTHESIS-STUTTGART, P118
[4] IMAI K, 1964, CHEM PHARM BULL, V12, P1030
[5] KLEIN RS, 1978, J ORG CHEM, V43, P2583
[6] LEIMGRUBER W, 1971, 3RD INT C HET CHEM
[7] MITCHELL GN, 1974, J ORG CHEM, V36, P176
[8] TANAKA K, 1964, CHEM PHARM BULL, V12, P1024
[9] A DIDEAZATETRAHYDROFOLATE ANALOG LACKING A CHIRAL CENTER AT C-6, N-[4-[2-(2-AMINO-3,4-DIHYDRO-4-OXO-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID, IS AN INHIBITOR OF THYMIDYLATE SYNTHASE
TAYLOR, EC
KUHNT, D
SHIH, C
RINZEL, SM
GRINDEY, GB
BARREDO, J
JANNATIPOUR, M
MORAN, RG
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) : 4450 - 4454

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