PROPHYLACTIC ANTIBIOTICS IN BILIARY AND LIVER SURGERY

Today, hepatic and biliary surgery includes conventional biliary surgery, laparoscopic surgery, interventional radiology, endoscopy and hepatic resection surgery. In conventional biliary surgery, the benefit of antibiotic prophylaxis has been demonstrated. Among the risk factors, some are specific (age > 65 years, gallstones in the common bile duct with or without jaundice, history of acute cholecystitis or of biliary surgery) and the others are non specific such as the CDC new index risk (for scoring from 0 to 3, wound infection rates are respectively 1.36, 2.01, 7.11, 11.54%). The targets for antibiotics used in conventional biliary surgery are E. coli, Klebsiella and Streptococcus. In biliary laparoscopic surgery, the rate of infectious complications and results of antibiotic prophylaxis have not been assessed. However, in laparoscopic surgery, the use of an antibiotic prophylaxis similar to that employed in conventional biliary surgery seems logical. In interventional radiology and endoscopy, the modalities and the benefit of antibiotic prophylaxis have not yet been assessed. Infections (angiocholecystitis) secondary to these procedures are frequent and severe. They are due to multiresistant hospital microorganisms. Antibiotic prophylaxis regimens for hepatic resections have not yet been assessed and are the same as for conventional biliary surgery.