NONINVASIVE TESTS FOR DIAGNOSIS OF CHLAMYDIA-TRACHOMATIS INFECTION - APPLICATION OF LIGASE CHAIN-REACTION TO FIRST-CATCH URINE SPECIMENS OF WOMEN

被引:109
作者
SCHACHTER, J
MONCADA, J
WHIDDEN, R
SHAW, H
BOLAN, G
BURCZAK, JD
LEE, HH
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,CHLAMYDIA RES LAB,SAN FRANCISCO,CA
[2] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA
[3] SAN FRANCISCO GEN HOSP,MED CTR,FAMILY PLANNING CLIN,SAN FRANCISCO,CA 94110
[4] UNIV CALIF SAN FRANCISCO,DEPT OBSTET GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94110
[5] CITY & CTY SAN FRANCISCO,DEPT PUBL HLTH,SAN FRANCISCO CITY CLIN,SAN FRANCISCO,CA
[6] ABBOTT LABS,PROBE DIAGNOST BUSINESS UNIT,ABBOTT PK,IL 60064
关键词
D O I
10.1093/infdis/172.5.1411
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Ligase chain reaction (LCR) to diagnose Chlamydia trachomatis infection was evaluated using first-catch urine (FCU) specimens from 4053 women. Results were compared with those of cell culture (TC) isolation from cervix (all) and urethra (2812 women). The reference standard was TC positivity or positive LCR for chlamydial plasmid DNA confirmed by direct fluorescent antibody test or LCR for another chlamydial gene. Compared with cervical culture, LCR was 88.2% sensitive and 100% specific. Adding urethral culture increased TC sensitivity from 67.1% to 74% and reduced LCR sensitivity to 85.9%. The prevalence of chlamydial infection was 5% (142/2812) by the dual culture system and 5.9% (165/2812) by LCR on FCU specimens. LCR on FCU specimens is highly sensitive and specific for diagnosing chlamydial infection. It is more sensitive than TC and may well present public health authorities with a useful noninvasive screening test for chlamydial infection in asymptomatic women.
引用
收藏
页码:1411 / 1414
页数:4
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