OOCYTE-SPECIFIC EXPRESSION OF GROWTH-DIFFERENTIATION FACTOR-IX

被引:411
作者
MCGRATH, SA [1 ]
ESQUELA, AF [1 ]
LEE, SJ [1 ]
机构
[1] JOHNS HOPKINS UNIV, SCH MED, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA
关键词
D O I
10.1210/me.9.1.131
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Growth/differentiation factor-9 (GDF-9) is a previously described member of the transforming growth factor-beta superfamily expressed specifically in the ovary in adult mice. Using in situ hybridization methods, we have localized the expression of GDF-9 messenger RNA (mRNA) exclusively to oocytes. GDF-9 mRNA was detected in oocytes at ail stages of follicular development, except in primordial follicles, in both neonatal and adult ovaries. GDF-9 mRNA continued to be expressed in oocytes after ovulation, but disappeared by 1.5 days after fertilization. Based on Western analysis of ovarian extracts using antibodies raised against recombinant GDF-9 protein, GDF-9 mRNA expressed by oocytes appears to be translated. A human homolog of GDF-9 was isolated from a complementary DNA library prepared from adult ovary mRNA. The predicted human protein is 90% identical to murine GDF-9 in the mature portion of the molecule. These results are significant because no other growth factor-like molecules have been shown to be expressed specifically by oocytes and, together with results of previous studies, suggest that ovarian development and function are regulated by factors produced by both oocytes and support cells of the ovary.
引用
收藏
页码:131 / 136
页数:6
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